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Elucidation of Functional Roles of Sialic Acids in Cancer Migration

Sialic acids (SA), negatively charged nine-carbon sugars, have long been implicated in cancer metastasis since 1960's but its detailed functional roles remain elusive. We present a computational analysis of transcriptomic data of cancer vs. control …

Neural Functions Play Different Roles in Triple Negative Breast Cancer (TNBC) and non-TNBC

Triple negative breast cancer (TNBC) represents the most malignant subtype of breast cancer, and yet our understanding about its unique biology remains elusive. We have conducted a comparative computational analysis of transcriptomic data of TNBC and …

Metabolic Reprogramming in Cancer is Induced to Increase Proton Production

Considerable metabolic reprogramming has been observed in a conserved manner across multiple cancer types, but their true causes remain elusive. We present an analysis of around 50 such reprogrammed metabolisms (RMs) including the Warburg effect, …

Transcription regulation by DNA methylation under stressful conditions in human cancer

We aim to address one question: do cancer vs. normal tissue cells execute their transcription regulation essentially the same or differently, and why? We utilized an integrated computational study of cancer epigenomes and transcriptomes of 10 cancer …